Relación bidireccional entre diabetes mellitus y periodontitis apical.
DOI:
https://doi.org/10.11565/arsmed.v43i3.1032Palabras clave:
diabetes mellitus, hemoglobina glicosilada, endodoncia, tejidos periapicales, periodontitis apical, reacción inflamatoria.Resumen
Resumen: La Diabetes Mellitus es una enfermedad crónica que ha ido en aumento en las últimas décadas, por lo que cada vez es más probable que los odontólogos veamos pacientes con esta enfermedad. Múltiples estudios han evaluado la relación entre diabetes mellitus y patologías orales, ya que la diabetes produce un estado proinflamatorio permanente que altera la cicatrización y la respuesta del hospedero frente a las bacterias. Â Por otro lado, la periodontitis apical, una de las patologías orales de mayor prevalencia en Chile, produce citoquinas que van a llegar al torrente sanguíneo, aumentando la inflamación y empeorando el control metabólico de esta enfermedad. El objetivo de esta revisión narrativa es entender los mecanismos por los que ocurre esta interacción y sus consideraciones terapéuticas.
Descargas
Citas
Aminoshariae A, Kulild JC, Mickel A. & Fouad, AF. (2017). Association between Systemic Diseases and Endodontic Outcome: A Systematic Review. Journal of Endodontics 43, 514-519 DOI: https://doi.org/10.1016/j.joen.2016.11.008
Aschner P, Aguilar-Salinas C, Aguirre L, Franco L, Gagliardino JJ, De Lapertosa SG, Seclen S. & Vinocour, M. (2014). Diabetes in South and Central America: An update Diabetes Research and Clinical Practice 103, 238–243. DOI: https://doi.org/10.1016/j.diabres.2013.11.010
Astolphi RD ,Curbete MM, Colombo NH, Shirakashi DJ, Chiba FY, Prieto AKC, Cintra LTA, Bomfim SRM, Ervolino E. & Sumida DH. (2013). Periapical lesions decrease insulin signal and cause insulin resistance Journal of Endodontics 39, 648–652. DOI: https://doi.org/10.1016/j.joen.2012.12.031
Bansal S, Siddarth M, Chawla D, Banerjee BD, Madhu SV & Tripathi AK. (2012). Advanced glycation end products enhance reactive oxygen and nitrogen species generation in neutrophils in vitro Molecular and cellular biochemistry 361, 289–96 DOI: https://doi.org/10.1007/s11010-011-1114-9
Bender IB. & Bender AB. (2003). Diabetes mellitus and the dental pulp Journal of endodontics 29, 383–9 DOI: https://doi.org/10.1097/00004770-200306000-00001
Bian Z, Guo Y, Ha B, Zen K & Liu Y.(2012). Regulation of the inflammatory response: enhancing neutrophil infiltration under chronic inflammatory conditions Journal of immunology 188, 844–53. DOI: https://doi.org/10.4049/jimmunol.1101736
Chandra A .(2009).Discuss the factors that affect the outcome of endodontic treatment Australian endodontic journal : the journal of the Australian Society of Endodontology Inc 35, 98–107 DOI: https://doi.org/10.1111/j.1747-4477.2009.00199.x
Cintra LT, Samuel RO, Azuma MM, Ribeiro CP, Narciso LG, De Lima VMF, Sumida DH, Coclete GA, Dezan-Júnior E & Gomes-Filho JE. (2014). Apical periodontitis and periodontal disease increase serum IL-17 levels in normoglycemic and diabetic rats Clinical Oral Investigations 18, 2123–2128. DOI: https://doi.org/10.1007/s00784-014-1192-7
Cintra LTA, Samuel RO, Facundo ACS, Prieto AKC, Sumida DH, Bomfim SRM, Souza JC, Dezan-Júnior E. & Gomes-Filho JE. (2014). Relationships between oral infections and blood glucose concentrations or HbA1c levels in normal and diabetic rats International Endodontic Journal 47, 228–237. DOI: https://doi.org/10.1111/iej.12136
Expert Committee on the Diagnosis and Classification of Diabetes Mellitus. (2003). Report of the expert committee on the diagnosis and classification of diabetes mellitus Diabetes care 26, 5-20. DOI: https://doi.org/10.2337/diacare.26.2007.S5
Fouad AF. (2003). Diabetes mellitus as a modulating factor of endodontic infections Journal of dental education 67, 459–467. DOI: https://doi.org/10.1002/j.0022-0337.2003.67.4.tb03647.x
Fouad AF & Burleson J.(2003). The effect of diabetes mellitus on endodontic treatment outcome: data from an electronic patient record Journal of the American Dental Association 134, 43-51 DOI: https://doi.org/10.14219/jada.archive.2003.0016
Garber SE, Shabahang S, Escher AP & Torabinejad M. (2009) The Effect of Hyperglycemia on Pulpal Healing in Rats Journal of Endodontics 35, 60–62. DOI: https://doi.org/10.1016/j.joen.2008.09.010
Garg R, Tripathy D & Dandona P. (2003). Insulin resistance as a proinflammatory state: mechanisms, mediators, and therapeutic interventions Current drug targets 4, 487–492 DOI: https://doi.org/10.2174/1389450033490920
Garrido M, DezeregaA, Bordagaray MJ, Reyes M, Vernal R, Melgar-Rodríguez S, Ciuchi P, Paredes R, García-Sesnich J, Ahumada-Montalva P. & Hernández M.(2015). C-reactive protein expression is up-regulated in apical lesions of endodontic origin in association with interleukin-6 Journal of endodontics 41, 464–9. DOI: https://doi.org/10.1016/j.joen.2014.12.021
Gionfriddo MR, McCoy RG & Lipska KJ .(2014). The 2013 American Association of Clinical Endocrinologists Diabetes Mellitus Management Recommendations JAMA Internal Medicine 174, 179. DOI: https://doi.org/10.1001/jamainternmed.2013.12971
Gomes MS, Blattner TC, Sant’Ana Filho M, Grecca FS, Hugo FN, Fouad AF & Reynolds MA .(2013). Can apical periodontitis modify systemic levels of inflammatory markers? A systematic review and meta-analysis Journal of Endodontics 39, 1205–1217. DOI: https://doi.org/10.1016/j.joen.2013.06.014
Graves DT, Oates T & Garlet GP .(2011). Review of osteoimmunology and the host response in endodontic and periodontal lesions Journal of Oral Microbiology 3, 5304. DOI: https://doi.org/10.3402/jom.v3i0.5304
Henriques LCF, De Brito LCN, Tavares WLF, Vieira LQ & Ribeiro Sobrinho AP .(2011). Cytokine analysis in lesions refractory to endodontic treatment Journal of Endodontics 37, 1659–1662. DOI: https://doi.org/10.1016/j.joen.2011.08.007
Iwama A, MorimotoT, Tsuji M, Nakamura K, Higuchi N, Imaizumi I, Shibata N, Yamasaki M & Nakamura H. (2006). Increased number of anaerobic bacteria in the infected root canal in type 2 diabetic rats Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics 101, 681–6. DOI: https://doi.org/10.1016/j.tripleo.2005.06.007
Lecka-Czernik B.(2010). Bone loss in diabetes: Use of antidiabetic thiazolidinediones and secondary osteoporosis Current Osteoporosis Reports 8, 178–184. DOI: https://doi.org/10.1007/s11914-010-0027-y
Leite MF, Ganzerla E, Marques MM & Nicolau J.(2008) Diabetes Induces Metabolic Alterations in Dental Pulp Journal of Endodontics 34, 1211–1214. DOI: https://doi.org/10.1016/j.joen.2008.07.010
Leite MF, De Lima A, Massuyama MM & Otton R .(2010). In vivo astaxanthin treatment partially prevents antioxidant alterations in dental pulp from alloxan-induced diabetic rats International Endodontic Journal 43, 959–967 DOI: https://doi.org/10.1111/j.1365-2591.2010.01707.x
Lima SMF, Grisi DC, Kogawa EM, Franco OL, Peixoto VC, Gonçalves-Júnior J F, Arruda MP & Rezende TMB. (2013). Diabetes mellitus and inflammatory pulpal and periapical disease: a review, International Endodontic Journal 46, 700–709. DOI: https://doi.org/10.1111/iej.12072
López-López J, Jané-Salas E, Estrugo-Devesa A, Velasco-Ortega E, Martín-González J & Segura-Egea JJ.(2011). Periapical and endodontic status of type 2 diabetic patients in Catalonia, Spain: A cross-sectional study Journal of Endodontics 37, 598–601. DOI: https://doi.org/10.1016/j.joen.2011.01.002
Marotta PS, Fontes TV, Armada L, Lima KC, Rocas IN & Siqueira JF Jr .(2012). Type 2 diabetes mellitus and the prevalence of apical periodontitis and endodontic treatment in an adult Brazilian population J Endod 38, 297–300. DOI: https://doi.org/10.1016/j.joen.2011.11.001
Mbalaviele G, Novack DV, Schett G & Teitelbaum SL .(2017). Inflammatory osteolysis: a conspiracy against bone Journal of Clinical Investigation 127, 2030-2039 DOI: https://doi.org/10.1172/JCI93356
Mealey, B. L. and Oates, T. W. (2006). Diabetes mellitus and periodontal diseases Journal of periodontology 77, 1289–303 DOI: https://doi.org/10.1902/jop.2006.050459
Sánchez-Domínguez B, López-López J, Jané-Salas E, Castellanos-Cosano L, Velasco-Ortega E. & Segura-Egea JJ. (2015). Glycated Hemoglobin Levels and Prevalence of Apical Periodontitis in Type 2 Diabetic Patients, Journal of Endodontics 41, 601–606. DOI: https://doi.org/10.1016/j.joen.2014.12.024
Saoud TM, Martin G, Chen YHM, Chen KL, Chen CA, Songtrakul K, Malek M, Sigurdsson A & Lin LM.(2016). Treatment of Mature Permanent Teeth with Necrotic Pulps and Apical Periodontitis Using Regenerative Endodontic Procedures: A Case Series Journal of Endodontics 42, 57-65 DOI: https://doi.org/10.1016/j.joen.2015.09.015
Sasaki H, Hirai K, Martins CM, Furusho H, Battaglino R & Hashimoto K. (2016). Interrelationship between Periapical Lesion and Systemic Metabolic Disorders Current pharmaceutical design 22, 2204–2215. DOI: https://doi.org/10.2174/1381612822666160216145107
Segura-Egea JJ, Castellanos-Cosano L, Machuca G, López-López J, Martín-González J, Velasco-Ortega E, Sánchez-Domínguez B. & López-Frías FJ. (2012). Diabetes mellitus, periapical inflammation and endodontic treatment outcome Medicina Oral, Patologia Oral y Cirugia Bucal 17, e356-61 DOI: https://doi.org/10.4317/medoral.17452
Segura-Egea JJ, Jiménez-Pinzón A, Ríos-Santos JV, Velasco-Ortega E, Cisneros-Cabello R & Poyato-Ferrera, M. (2005). High prevalence of apical periodontitis amongst type 2 diabetic patients International Endodontic Journal 38, 564–569. DOI: https://doi.org/10.1111/j.1365-2591.2005.00996.x
Segura-Egea JJ, Martín-González J, Cabanillas-Balsera D, Fouad AF, Velasco-Ortega E. & López-López J .(2016). Association between diabetes and the prevalence of radiolucent periapical lesions in root-filled teeth: systematic review and meta-analysis, Clinical Oral Investigations 20, 1133-41 DOI: https://doi.org/10.1007/s00784-016-1805-4
Segura-Egea JJ, Martín-González J & Castellanos-Cosano, L. (2015). Endodontic medicine: Connections between apical periodontitis and systemic diseases International Endodontic Journal 48, 933–951. DOI: https://doi.org/10.1111/iej.12507
Vivekananda Pai A, Pai S, Thomas M & Bhat V .(2014). Effect of calcium hydroxide and triple antibiotic paste as intracanal medicaments on the incidence of inter-appointment flare-up in diabetic patients: An in vivo study Journal of Conservative Dentistry 17, 208 -211 DOI: https://doi.org/10.4103/0972-0707.131776
Wieser V, Moschen AR & Tilg H (2013) Inflammation, cytokines and insulin resistance: A clinical perspective, Archivum Immunologiae et Therapiae Experimentalis 61, 119–125. DOI: https://doi.org/10.1007/s00005-012-0210-1
Wittrant Y, Gorin Y, Woodruff K, Horn D, Abboud HE, Mohan S & Abboud-Werner SL. (2008). High d(+)glucose concentration inhibits RANKL-induced osteoclastogenesis Bone 42, 1122–1130. DOI: https://doi.org/10.1016/j.bone.2008.02.006
Zhen D, Chen Y & Tang, X. (2010). Metformin reverses the deleterious effects of high glucose on osteoblast function Journal of Diabetes and its Complications 24, 334–344 DOI: https://doi.org/10.1016/j.jdiacomp.2009.05.002
Zimmet P, Alberti KG & Shaw J. (2001). Global and societal implications of the diabetes epidemic Nature 414, 782–787. DOI: https://doi.org/10.1038/414782a
Descargas
Publicado
Cómo citar
Licencia
Derechos de autor 2018 ARS MEDICA Revista de Ciencias Médicas
Esta obra está bajo una licencia internacional Creative Commons Atribución-CompartirIgual 4.0.
Los autores/as conservan sus derechos de autor y garantizan a la revista el derecho de primera publicación de su obra, la que estará simultáneamente sujeta a la Licencia CC BY-SA 4.0 (Ver declaración de Acceso Abierto).
